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Argonaute 3 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q9H9G7 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 97360 Da |
| Gene ID | 192669 |
|---|---|
| Other Names | Protein argonaute-3 {ECO:0000255|HAMAP-Rule:MF_03032}, Argonaute3 {ECO:0000255|HAMAP-Rule:MF_03032}, hAgo3, 3.1.26.n2, Argonaute RISC catalytic component 3, Eukaryotic translation initiation factor 2C 3 {ECO:0000255|HAMAP-Rule:MF_03032}, eIF-2C 3 {ECO:0000255|HAMAP-Rule:MF_03032}, eIF2C 3 {ECO:0000255|HAMAP-Rule:MF_03032}, AGO3, EIF2C3 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | AGO3 |
|---|---|
| Synonyms | EIF2C3 |
| Function | Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA- dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity (PubMed:29040713). |
| Cellular Location | Cytoplasm, P-body {ECO:0000255|HAMAP- Rule:MF_03032, ECO:0000269|PubMed:16081698} |
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP54874
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